Cannabinoid Compositions

ABSTRACT

A cannabinoid composition including a cannabinoid oil, such as THC oil or CBD oil, one or more thickeners such as gums, and a compound that forms an inclusion complex with the cannabinoid oil. The composition may include water, and in intermediate stages can include an alcohol. The composition can also include a sweetener to make it a sugar or a syrup. In some embodiments there are no other oils in the composition.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a Continuation-in-Part application of U.S. patentapplication Ser. No. 16/161,027, filed on Oct. 15, 2018, issuing as U.S.Pat. No. 10,624,844 on Apr. 21, 2020, which application is aContinuation-in-Part application of International Application No.PCT/US2017/027550 filed Apr. 14, 2017 and from International ApplicationNo. PCT/US2017/027549 filed Apr. 14, 2017, and from InternationalApplication No. PCT/US2017/027543 filed Apr. 14, 2017 which all claimpriority to and the benefit of U.S. Provisional Application No.62/323,154 filed Apr. 15, 2016 and U.S. Provisional Application No.62/328,975 filed Apr. 28, 2016, and the specification and claims thereofare incorporated herein by reference.

FIELD OF THE INVENTION

Embodiments of the present invention relate to a method of makingCannabis oil hydrophilic using emulsifiers. More particularly,embodiments of the present invention relate to a water-solublecannabinoid composition, a cannabinoid composition with caffeineemulsification, Cannabis oil infused sweeteners and elixir that may bebio-available, fast acting and highly metabolizable.

BACKGROUND OF THE INVENTION

Cannabinoids are chemical compounds found in the Cannabis plant thatinteract with receptors in the brain and body to create various effects.Herbal Cannabis contains over 400 compounds including over 100cannabinoids, which are aryl-substituted meroterpenes unique to theplant genus Cannabis. The pharmacology of most of the cannabinoids islargely unknown but the most potent psychoactive agent,Δ⁹-tetrahydrocannabinol (Δ⁹-THC, or THC), has been isolated, synthesizedand much studied due to its abundance and psychoactive attributes. Otherplant cannabinoids include Δ⁸-THC, cannabinol and cannabidiol (CBD).These and other cannabinoids have additive, synergistic or antagonisticeffects with THC and may modify its actions when herbal Cannabis issmoked.

The best studied cannabinoids include tetrahydrocannabinol (THC),cannabidiol (CBD) and cannabinol (CBN). These structures are shown inFIG. 1. All cannabinoids derive from cannabigerol-type compounds anddiffer mainly in the way this precursor is cyclized. The classicalcannabinoids are derived from their respective 2-carboxylic acids(2-COOH) by decarboxylation (catalyzed by heat, light, or alkalineconditions).

The isolation of THC came from an Israeli chemist by the name of RaphaelMechoulam. In 1964, Mechoulam isolated and synthesized THC from Lebanesehashish, marking the beginning of Cannabis research that would lead tothe discovery of many other cannabinoids, cannabinoid receptorsthroughout the body, and “endocannabinoids”—the THC-like compounds thehuman body naturally produces to maintain stability and health.

CBD and THC levels tend to vary among different plants. Marijuana grownfor recreational purposes often contains more THC than CBD. However, byusing selective breeding techniques, Cannabis breeders can createvarieties with high levels of CBD and next to zero levels of THC.

Humans and many other animals have receptor systems that THC binds to,and therefore can also reap the benefits of cannabinoids for both healthand enjoyment. The endocannabinoid system (or “ECS”), is a group ofspecialized signaling chemicals, their receptors, and the metabolicenzymes that produce and break them down. These endocannabinoid chemicalsignals act on some of the same brain and immune cell receptors (CB1 andCB2) that plant cannabinoids like CBD and THC act on.

THC works by binding to cannabinoid receptors concentrated in the brainand central nervous system to produce psychoactive effects. The maindifference between THC and CBD, both of which are very popularcannabinoids, is in their psychoactive effects. THC elicits strongcerebral euphoria, while CBD lacks psychoactive effects altogether. Thisbasically comes down to the fact that THC activates CB1 receptors in thehuman brain while CBD does not.

It is well known that cannabinoids, especially CBD and THC have manymedicinal benefits. CBD's subtle effects are primarily felt in pain,inflammation, and anxiety relief, as well as other medicinal benefits.CBD also does not have any adverse side effects that may occur withconsumption of THC. Unlike THC, CBD also does not cause a high. Thismakes CBD a significant advantage as a medicine, since healthprofessionals prefer treatments with minimal side effects. CBD alsoappears to counteract the sleep-inducing effects of THC, which mayexplain why some strains of Cannabis are known to increase alertness.CBD also acts to reduce the intoxicating effects of THC, such as memoryimpairment and paranoia.

THC has a wide range of short-term effects which may or may not beexperienced depending on the individual and their body chemistry. Somepositive short-term effects of THC include: elation, relaxation,sedation, pain relief, energy, hunger, drowsiness, slowed perception oftime and laughter.

There are a variety of medical conditions for which THC offers benefits.The conditions include Post Traumatic Stress Disorder, neuropathic andchronic pain, insomnia, nausea, inflammation, arthritis, migraines,Cancer, Crohn's disease, fibromyalgia, Alzheimer's disease, Multiplesclerosis, Glaucoma, Attention deficit hyperactivity disorder (“ADHD”),sleep apnea and appetite loss.

Both CBD and THC have been found to present no risk of lethal overdose.However, to reduce potential side effects, medical users are better offusing Cannabis with higher levels of CBD.

Today the most common way to consume THC is through smoking althoughthey can be consumed orally. However, known methods for orallyadministered THC have reduced bioavailability due to low absorption andhigh first-pass metabolism in the digestive system. Thus, there is aneed for aqueous cannabinoid solutions.

Decarboxylation of the THC occurs with heating and is the key toenjoying THC, whether it is consumed by smoking or ingesting. In its rawform, Cannabis is non-psychoactive, with its primary cannabinoid beingTHCA. However, by applying heat, either when lighting it in a pipe orcooking it into oil, the THCA is converted to THC.

The invention method provides an advantageous alternative to smokingCannabis by providing a water-soluble cannabinoid composition for oralingestion that is bioavailable, highly metabolizable and fast acting.

As an aromatic terpenoid, THC has a very low solubility in water, butgood solubility in most organic solvents, specifically lipids andalcohols.

The problem with edible Cannabis products is they take a varied amountof time to take effect due to the liver's varied ability to process theTHC molecule. Depending on liver function at the time, between 2-6% ofthe THC is able to be metabolized. This process makes it so the THC isabsorbed in the esophagus and soft tissues, making it faster acting andmore highly metabolizable.

Unlike anything currently known, one or more purposes of embodiments ofthe present invention is to provide a water-soluble cannabinoidcomposition, and/or a cannabinoid emulsification (with or withoutcaffeine), and/or Cannabis infused sweeteners and Cannabis infusedelixirs to create Cannabis oil infused products for medical andrecreational use that are bioavailable, fast acting and highlymetabolized, with consistent results that take place in a consistentamount of time. In general, elixirs are healing botanicals known toaddress specific imbalances yet, they are not necessarily teaching thebody to mimic the healing chemistry in order for the body to continuehealing. Also, elixirs are made with delicious flavoring agents, flowersand healthy sweeteners, as well as use a different ratio of medicinalpotency. Elixirs are usually a 1:3 or 1:4 in liquid to herb extraction.

In making the sweeteners and elixirs according a method of the presentinvention, a method to make Cannabis oil water-soluble is used whichuses a combination of emulsifiers and variations in time and temperatureof the reaction steps. The process results in a Cannabis infusedsweeteners and elixirs which provide fast acting, bioavailability andhighly metabolizable delivery of the Cannabis oil, either alone or incombination with other edible products.

Another purpose of the invention is to provide a line of Cannabis oilinfused sugars and elixirs that share a base of coconut water infusedwith coconut fat and to sell the products to wholesale distributors forretail sale in legal dispensaries.

A purpose of an embodiment of the invention is to provide a method tomake Cannabis oil water-soluble using a combination of emulsifiers andvariations in time and temperature of the reaction steps. One result ofthe process is a water-soluble, hydrophilic cannabinoid composition,and/or a cannabinoid emulsification and/or Cannabis infused sweetenersand Cannabis infused elixirs which can be used in a variety of edibleproducts providing fast acting, bioavailability and highly metabolizabledelivery of the Cannabis oil.

Another purpose of the invention is to provide a line of Cannabis oiland caffeine edible products that share a base of coconut water infusedwith coconut fat and to sell the products to wholesale distributors forretail sale in legal dispensaries.

Another purpose of the invention is to provide a line of Cannabis oiland caffeine infused sugars and elixirs that share a base of coconutwater infused with coconut fat and to sell the products to wholesaledistributors for retail sale in legal dispensaries.

More specifically a purpose of the invention is to use the water-solublecannabinoid composition, and/or a cannabinoid emulsification and/or aCannabis infused sweeteners and elixirs to treat Post Traumatic StressDisorder, neuropathic and chronic pain, insomnia, nausea, inflammation,arthritis, migraines, Cancer, Crohn's disease, fibromyalgia, Alzheimer'sdisease, Multiple sclerosis, Glaucoma, Attention deficit hyperactivitydisorder (“ADHD”), sleep apnea and appetite loss.

Yet another purpose of an embodiment of the water-soluble Cannabis oilcomposition, and/or emulsification, and/or sugars and elixirs is totreat pain, inflammation, and anxiety relief.

More specifically, the water-soluble Cannabis oil composition, and/orthe emulsification, and/or the sugars and elixirs can be combined withchocolate and/or liquor to create edible products.

Yet another purpose of embodiments of the present invention providesthat the composition, emulsification, and/or sugars and elixirs can beused to produce other edible products at home or professionally withpredictable results, including being fast-acting, and highlymetabolizable, which are referred to herein as super-charged. This letsconsumers know that the invention products have markedly differentresults than other products. These compositions can be marketed in manyforms, both in retail and wholesale manufacturing, as well as aidingcompanies with quality products to use for research and development.

SUMMARY OF THE INVENTION

In one or more embodiments of the present invention, the above purposes,as well as others which will be apparent, are achieved generally by amethod of making Cannabis oil hydrophilic by using a combination ofemulsifiers and variations in time and temperature of the reactionsteps, and/or cannabinoid emulsification made of at least oneemulsifying agent; an aqueous vehicle; a base oil; Cannabis oil; andcaffeine, and/or Cannabis infused sweetener comprising Cannabis oil; atleast one emulsifying agent selected from the group consisting ofxanthan gum, guar gum, lecithin, carrageen, monoglycerides, naturalemulsifiers and organic emulsifiers that are safe for ingestion byhumans and a sweetener. The resulting cannabinoid emulsification isbio-available, highly metabolizable and fast acting when ingested by theuser.

In one embodiment, the specific steps in making the Cannabis oilhydrophilic include first heating a base oil in the range of about 120to 220° F. The Cannabis oil is added to this heated oil (pre heating orpost heating) to create a mixture which is then blended at a high speed.At least one emulsifying agent is added to the hot mixture whileblending is continued. Water is then added to form the compositionwherein the Cannabis oil is hydrophilic and is soluble in water.

This method modifies normally hydrophobic, or “water-repelling”,Cannabis oil into a hydrophilic Cannabis oil alone or when combined withone or more of the following: an emulsification, sweetener/sugar and/orelixir that is bio-available, highly metabolizable and fast acting wheningested by the user. The Cannabis oil produced by this method issuitable for use in emulsifications and a component of sugars andelixirs.

It is a preferred process parameter that while blending the mixture itis maintained at a temperature in the range of about 120 to 220° F.

In one embodiment, a sweetener used is selected from the groupconsisting of white sugar, cane sugar, raw sugar, fructose, turbinadosugar, coconut sugar, date sugar, liquid stevia, liquid sugar, powderedsugar, brown sugar, muscovado sugar, honey, agave and other likesweeteners. The sweetener component is present in the range of about 98%to about 99.88% of the Cannabis infused sweetener. Alternatively, thesweetener is present in the range of about 50%-60%, 60-70%, 70-80%,80-90% or 90-99.9% for example.

At least one emulsifying agent is used in the invention process which isselected from the group consisting of xanthan gum, guar gum,cyclodextrin, lecithin, carrageen, monoglycerides, natural emulsifiersand organic emulsifiers that are safe for ingestion by humans.

A Cannabis oil is selected from the group consisting oftetrahydrocannabinol (THC), cannabidiol (CBD) and other cannabinoid oilsisolated from the marijuana plant. The Cannabis oil is present in therange of about 1.5 mg to 20 mg per gram of sweetener.

The emulsifying agent is present in the range of about 0.12% to 2% ofthe total sweetener. In preferred embodiments, the emulsifying agent isa combination of at least two emulsifying agents which can be the sameor different. In a preferred embodiment, the emulsifying agents includecyclodextrin in combination with at least one selected from the groupconsisting of xanthan gum, guar gum, lecithin, carrageen,monoglycerides, natural emulsifiers and organic emulsifiers that aresafe for ingestion by humans.

The aqueous vehicle is selected from the group consisting of coconutwater, fruit juice, milk and water. The aqueous vehicle is in the rangeof about 60% to 99.9% of the emulsification. The preferred vehicle iscoconut water. Alternatively, the aqueous vehicle is present in therange of about 50%-60%, 60-70%, 70-80%, 80-90% or 90-99.9% for example.

The base oil is selected from the group consisting of vegetableglycerine, almond oil, avocado oil, canola oil, coconut oil, corn oil,cottonseed oil, grapeseed oil, hazelnut oil, olive oil, extra virginolive oil, palm oil, peanut oil, palm seed oil, pumpkin seed oil,safflower oil, sesame oil, soy oil, sunflower oil, vegetable oil andwalnut oil and any oil high in saturated fats. The base oil ispreferably in the range of about 0.1% to 40% of the emulsification.Alternatively, the base oil is present in the range of about 0.1%-5%,5-10%, 10-20%, 20-30% or 30-40% for example.

The Cannabis oil used in the invention is in a pure state. The Cannabisoil used can be extracted from the marijuana plant by CO2 extraction,water extraction, butane extraction and extraction methods that leave azero testing for residuals.

The Cannabis oil used in the invention is selected from the groupconsisting of tetrahydrocannabinol (THC), cannabidiol (CBD) and othercannabinoid oils isolated from the marijuana plant.

In a preferred embodiment, a Cannabis infused elixir is providedcomprising Cannabis oil; at least one emulsifying agent; a sweetenerselected from the group consisting of white sugar, cane sugar, rawsugar, fructose, turbinado sugar, coconut sugar, date sugar, liquidstevia, liquid sugar, powdered sugar, brown sugar, muscovado sugar,honey, agave and other like sweeteners and flavoring extracts or fruitsyrups.

The sweetener is present in the range of about 98% to 99.8% of theelixir.

The Cannabis infused elixir includes Cannabis oil is bio-available,highly metabolizable and fast acting when ingested by the user.

As in the sweetener embodiment, the Cannabis oil used in the elixir isselected from the group consisting of tetrahydrocannabinol (THC),cannabidiol (CBD) and other cannabinoid oils isolated from the marijuanaplant. The Cannabis oil is present in the range of about 3 mg to 50 mgper ounce of elixir.

The Cannabis oil and/or elixir is added to the mixture or a drinksolution, such as a carbonated or flat water solution, in the range ofabout 5 mg to 20 mg per 2 ounces of the composition or a ratio betweenabout 1:3 to 1:4 to create a liquid beverage. The base oil is present inthe range of about 0.5 grams to 5 grams of base oil per about 1 ounce ofthe composition.

The emulsifying agent is in the range of about 0.15% and about 2% of thetotal volume of the emulsification and/or the emulsifying agent ispresent in the range of about 0.15% to about 2% of the elixir.

The invention also provides a water-soluble cannabinoid composition thatis bioavailable, fast acting and highly metabolizable.

The emulsifying agent is selected from the group consisting of xanthangum, guar gum, cyclodextrin, lecithin, carrageen, monoglycerides,natural emulsifiers and organic emulsifiers that are safe for ingestionby humans.

The base oil in the cannabinoid composition is preferably selected fromthe group consisting of vegetable glycerine, coconut oil and any oilhigh in saturated fats. However, other nut oils such as almond oil,avocado oil, canola oil, coconut oil, corn oil, cottonseed oil,grapeseed oil, hazelnut oil, olive oil, extra virgin olive oil, palmoil, peanut oil, palm seed oil, pumpkin seed oil, safflower oil, sesameoil, soy oil, sunflower oil, vegetable oil and walnut oil can be used asthe base oil.

The Cannabis oil in the composition is in a pure state that has beenextracted from the marijuana plant by CO2 extraction, water extraction,butane extraction and extraction methods that leave a zero testing forresiduals.

The Cannabis oil in the composition is selected from the groupconsisting of tetrahydrocannabinol (THC), cannabidiol (CBD) and othercannabinoid oils isolated from the marijuana plant.

Other ingredients such as chocolate and liquor can be added to thecomposition to provide different flavor profiles.

In a preferred embodiment the emulsifying agent is a combination of atleast two emulsifying agents. In a most preferred embodimentcyclodextrin is used in combination with at least one other emulsifyingagent selected from the group consisting of xanthan gum, guar gum,lecithin, carrageen, monoglycerides, natural emulsifiers and organicemulsifiers that are safe for ingestion by humans.

The Cannabis oil in the emulsification is in the range of about 5 mg to30 mg per 2 ounces of the emulsification.

Caffeine is present in one embodiment of the emulsification in the rangeof about 10 to 300 mg per 2 ounces of the emulsification. The caffeinecan be in anhydrous form.

In the emulsification the base oil to aqueous vehicle ratio is betweenabout 1 to 10 grams of base oil per about 2 ounces of theemulsification.

The invention also provides a method for making cannabinoidemulsifications comprising the steps of heating a base oil, preferablycoconut oil, to between about 120 to 220 degrees F. Adding at least oneemulsifying agent, caffeine and Cannabis oil to an aqueous vehicle andadding to the heated coconut oil to create a mixture. Blending themixture in a high speed machine, while holding the temperature betweenabout 120 to 220 degrees F. to emulsify the mixture and then addingcaffeine to the mixture.

The emulsifying agents are added in an amount between 0.15% and 2% ofthe total volume of the mixture and are selected from the groupconsisting of xanthan gum, guar gum, cyclodextrin, lecithin, carrageen,monoglycerides, natural emulsifiers and organic emulsifiers that aresafe for ingestion by humans.

The hot mixture is blended at high speed for between 30 seconds and 2minutes. The resulting cannabinoid emulsification is bio-available,highly metabolizable and fast acting when ingested by the user.

In preferred embodiments the emulsifying agent is a combination of atleast two emulsifying agents. In a most preferred embodiment theemulsifying agent is a combination of xanthan gum and cyclodextrin,where the cyclodextrin and xanthan gum are each present in the amount of0.12 to 2%.

An embodiment of the present invention is a cannabinoid infusedingestible composition comprising a cannabinoid oil; a compound thatforms an inclusion complex with the cannabinoid oil; and a thickener;wherein the cannabinoid oil is the only oil in the composition. Thecomposition preferably further comprises a sweetener. The sweetener ispreferably selected from the group consisting of white sugar, canesugar, raw sugar, fructose, turbinado sugar, coconut sugar, date sugar,stevia, liquid stevia, liquid sugar, powdered sugar, brown sugar,muscovado sugar, maple sugar, honey, and agave. The compound preferablycomprises cyclodextrin. The thickener preferably comprises a gum. Thegum preferably comprises xanthan gum. The cannabinoid preferablycomprises tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Thecannabinoid is preferably bio-available, highly metabolizable and fastacting when ingested. The compound and the thickener each preferablycomprise about 0.12% to 2% of the composition. The compositionpreferably comprises from about 0.01% to 4% of both the compound and thethickener, more preferably from about 0.15% to 3% of both the compoundand the thickener. The composition preferably comprises equalpercentages of the compound and the thickener.

Another embodiment of the present invention is a cannabinoid infusedcomposition consisting essentially of a cannabinoid oil; an alcohol;water; a compound that forms an inclusion complex with the cannabinoidoil; and a thickener. The compound preferably comprises cyclodextrin.The thickener preferably comprises a gum. The gum preferably comprisesxanthan gum. The cannabinoid preferably comprises tetrahydrocannabinol(THC) and/or cannabidiol (CBD). The cannabinoid is preferablybio-available, highly metabolizable and fast acting when ingested. Thecompound and the thickener each comprise 0.12% to 2% of the composition.The composition preferably comprises about 0.01% to 4% of both thecompound and the thickener, and more preferably about 0.15% to 3% ofboth the compound and the thickener. The composition preferablycomprises equal percentages of the compound and the thickener.

Another embodiment of the present invention is a cannabinoid infusedcomposition consisting essentially of a cannabinoid oil; water; acompound that forms an inclusion complex with the cannabinoid oil; athickener; and a sweetener. The sweetener is preferably selected fromthe group consisting of white sugar, cane sugar, raw sugar, fructose,turbinado sugar, coconut sugar, date sugar, stevia, liquid stevia,liquid sugar, powdered sugar, brown sugar, muscovado sugar, maple sugar,honey, and agave. The compound preferably comprises cyclodextrin. Thethickener preferably comprises a gum. The gum preferably comprisesxanthan gum. The cannabinoid preferably comprises tetrahydrocannabinol(THC) and/or cannabidiol (CBD). The compound and the thickener eachpreferably comprise about 0.12% to 2% of the composition. Thecomposition preferably comprises about 0.01% to 4% of both the compoundand the thickener, and more preferably about 0.15% to 3% of both thecompound and the thickener. The composition preferably comprises equalpercentages of the compound and the thickener.

Another embodiment of the present invention is a cannabinoid infusedcomposition consisting essentially of a cannabinoid oil; a compound thatforms an inclusion complex with the cannabinoid oil; a thickener; and asweetener. The sweetener is preferably selected from the groupconsisting of white sugar, cane sugar, raw sugar, fructose, turbinadosugar, coconut sugar, date sugar, stevia, liquid stevia, liquid sugar,powdered sugar, brown sugar, muscovado sugar, maple sugar, honey, andagave. The compound preferably comprises cyclodextrin. The thickenerpreferably comprises a gum. The gum preferably comprises xanthan gum.The cannabinoid preferably comprises tetrahydrocannabinol (THC) and/orcannabidiol (CBD). The compound and the thickener each preferablycomprise about 0.12% to 2% of the composition. The compositionpreferably comprises about 0.01% to 4% of both the compound and thethickener, and more preferably about 0.15% to 3% of both the compoundand the thickener. The composition preferably comprises equalpercentages of the compound and the thickener.

Other objects, features and advantages of the present invention will beapparent when the detailed description of the preferred embodiments ofthe invention is considered which should be construed in an illustrativeand not limiting sense.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

The accompanying drawings, which are incorporated into and form a partof the specification, illustrate one or more embodiments of the presentinvention and, together with the description, serve to explain theprinciples of the invention. The drawings are only for the purpose ofillustrating one or more embodiments of the invention and are not to beconstrued as limiting the invention. In the drawings:

FIG. 1 is the formula for THC, cannabinol and cannabidiol and structure;

FIG. 2 is the structure for Xanthan Gum;

FIG. 3 is the structure of Guar Gum.

FIG. 4 is a chemical structure and the molecular shape of B-cyclodextrin(BCD);

FIG. 5 is a chemical structure of Lecithin;

FIG. 6 is a chemical structure of Carrageen (kappa); and

FIG. 7 is a chemical structure of a monoglyceride.

DETAILED DESCRIPTION OF THE INVENTION

One embodiment of the present invention provides a method of makingCannabis oil hydrophilic. The process of the invention modifies normallyhydrophobic, or “water-repelling”, Cannabis oil into hydrophilicCannabis oil that is bio-available, highly metabolizable and fast actingwhen ingested by the user.

Another embodiment provides a unique emulsified combination of Cannabisoil, caffeine, and a base oil and aqueous vehicle, which arerespectively, preferably coconut oil, and coconut water. Coconut oil isone of the best sources of excellent fatty acids. Emulsified withcoconut water, Cannabis oil and caffeine provide a beneficial experiencefor people experiencing a variety of ailments: insomnia, muscle aches,anxiety, etc., or are in recovery from surgery, or in chemotherapy. Theemulsification makes the Cannabis oil molecules water-soluble, bymodification from its normal hydrophobic state into a hydrophilic(“water-loving”), which makes the Cannabis oil bioavailable, fasteracting, and more highly metabolizable.

Yet another embodiment provides a Cannabis infused sweetener comprisingCannabis oil; at least one emulsifying agent selected from the groupconsisting of xanthan gum, guar gum, lecithin, carrageen,monoglycerides, natural emulsifiers and organic emulsifiers that aresafe for ingestion by humans and a sweetener; and Cannabis infusedelixir comprising Cannabis oil; at least one emulsifying agent; asweetener selected from the group consisting of white sugar, cane sugar,raw sugar, fructose, turbinado sugar, coconut sugar, date sugar, liquidstevia, liquid sugar, powdered sugar, brown sugar, muscovado sugar,honey, agave and other like sweeteners and flavoring extracts or fruitsyrups.

In one instance, both sweetener and elixir embodiments the Cannabis oiltherein has been modified from its normal hydrophobic state into ahydrophilic (“water-loving”) state that is bio-available, highlymetabolizable and fast acting when ingested by the user.

Bioavailability refers to the degree to which food nutrients, in thisinvention, Cannabis oil, are available for absorption and utilization inthe body. Bioavailability typically applies to nutrients and drugs whichpass through first-pass metabolism, i.e. orally consumed substances.Anything absorbed in the gut first passes through the liver beforereaching the rest of the circulation, and both the gut and liver maymetabolize it to some extent.

Metabolizable refers to the process of changing food/substances into aform that can be used by your body.

The process steps of an embodiment of the invention include firstheating a base oil in the range of about 120 to 220° F. The Cannabis oilis added to this heated oil to create a mixture which is then blended ata high speed. At least one emulsifying agent is added to the hot mixturewhile blending is continued. Water is then added to form the compositionwherein the Cannabis oil is hydrophilic and is soluble in water.

It is a preferred process parameter that while blending the mixture itis maintained at a temperature in the range of about 120 to 220° F.

The cannabinoid emulsification embodiment of the invention is made of atleast one emulsifying agent; an aqueous vehicle; a base oil; Cannabisoil; and caffeine.

Emulsifiers

Emulsions are produced by dispersing normally unmixable material intoanother by mixing, colloidal milling or homogenization. Thesurface-active qualities of emulsifiers of the invention make themeffective emulsifying agents that reduce mixing time and maintain thestability of the dispersion.

The emulsifying agent in the invention is present in the range of about0.15% to 2% of the composition. At least one emulsifying agent is usedin the invention process which is selected from the group consisting ofxanthan gum, guar gum, cyclodextrin, lecithin, carrageen,monoglycerides, natural emulsifiers and organic emulsifiers that aresafe for ingestion by humans. In preferred embodiments, the emulsifyingagent is a combination of at least two different emulsifying agents.

Cannabis oil, including THC and CBD, are not water-soluble, so it needsto be “trapped” in something with dual polarity—that is, a compound thatreconciles the fact that water is polar and the cannabinoid is not. Theemulsifiers provide this. Once trapped in the compound, the THC has newde facto properties, like the ability to dissolve in water, distributeitself evenly, and stay suspended in the solution. It also displaysincreased bioavailability: while the same amount of Cannabis oil in anedible can take up to two hours to reach the bloodstream, the effects ofwater-soluble Cannabis oil dissolved in water can be felt more acutely,in as little as 10 minutes.

It is known that cannabinoids are soluble in fat. It is also known thatonly water-soluble substances can pass the intestine membrane. Fat isitself not water-soluble because it is like cannabinoids, uncharged. Fatabsorption into the membrane requires substances with a dipole characterto build up vehicles which can connect at the outer surface with water(charged side) and at the inner surface with the fat and the THC(uncharged side).

The specific emulsifiers used in the invention are detailed below.

Xanthan Gum

Xanthan gum, which is also called xanthene, has the chemical formulaC₁₃H₁₀O. Its molecular weight is 182.22 grams/mol. FIG. 2 shows thechemical structure of xanthan gum.

In general, xanthan gum is a substance made by fermenting bacteria withsugars. It is an additive found in both foods and medicines. As a foodadditive, this substance is utilized either as a thickener orstabilizer. This compound has a variety of uses in medicine, such as inthe treatment of diabetes, cholesterol and dry mouth.

Specifically, xanthan gum is a polysaccharide secreted by the bacteriumXanthomonas campestris. Its known uses, prior to the invention, is as afood additive and rheology modifier, commonly used as a food thickeningagent (in salad dressings, for example) and a stabilizer (in cosmeticproducts, for example, to prevent ingredients from separating). As seenin FIG. 1, it is composed of pentasaccharide repeat units, comprisingglucose, mannose, and glucuronic acid in the molar ratio 2:2:1. It isproduced by the fermentation of glucose, sucrose, or lactose. After afermentation period, the polysaccharide is precipitated from a growthmedium with isopropyl alcohol, dried, and ground into a fine powder.Later, it is added to a liquid medium to form the gum.

Guar Gum

Chemically, guar gum is a polysaccharide composed of the sugarsgalactose and mannose. FIG. 3 shows that the backbone is a linear chainof β1,4-linked mannose residues to which galactose residues are1,6-linked at every second mannose, forming short side-branches.

In water, guar gum is nonionic and hydrocolloidal. It is not affected byionic strength or pH, but will degrade at extreme pH and temperature(e.g. pH 3 at 50° C.). It remains stable in solution over pH range ofabout 5-7. Strong acids cause hydrolysis and loss of viscosity, andalkalis in strong concentration also tend to reduce viscosity. It isinsoluble in most hydrocarbon solvents. The viscosity attained isdependent on time, temperature, concentration, pH, rate of agitation andpractical size of the powdered gum used. The lower the temperature, thelower the rate at which viscosity increases and the lower the finalviscosity. Above 80°, the final viscosity is slightly reduced. The finerguar powders swell more rapidly than coarse powdered gum. Guar gum hasalmost eight times the water-thickening potency of cornstarch—only avery small quantity is needed for producing sufficient viscosity. Thus,it can be used in various multiphase formulations: as an emulsifierbecause it helps to prevent oil droplets from coalescing, and/or as astabilizer because it helps to prevent solid particles from settling.

Cyclodextrin

Cyclodextrins are a group of structurally related natural productsformed during bacterial digestion of cellulose. These cyclicoligosaccharides consist of (α-1,4)-linked α-D-glucopyranose units andcontain a somewhat lipophilic central cavity and a hydrophilic outersurface. Due to the chair conformation of the glucopyranose units, thecyclodextrins are shaped like a truncated cone rather than perfectcylinders. The hydroxyl functions are oriented to the cone exterior withthe primary hydroxyl groups of the sugar residues at the narrow edge ofthe cone and the secondary hydroxyl groups at the wider edge. Thecentral cavity is lined by the skeletal carbons and ethereal oxygens ofthe glucose residues, which gives it a lipophilic character. Thepolarity of the cavity has been estimated to be similar to that of anaqueous ethanolic solution.

The natural α-, β- and γ-cyclodextrin (αCD, βCD and γCD) consist of six,seven, and eight glucopyranose units, respectively. The naturalcyclodextrins, in particular βCD, are of limited aqueous solubilitymeaning that complexes resulting from interaction of lipophiles withthese cyclodextrin can be of limited solubility resulting inprecipitation of solid cyclodextrin complexes from water and otheraqueous systems. In fact, the aqueous solubility of the naturalcyclodextrins is much lower than that of comparable acyclic saccharides.This is thought to be due to relatively strong intermolecular hydrogenbonding in the crystal state. Substitution of any of the hydrogen bondforming hydroxyl groups, even by lipophilic methoxy functions, resultsin dramatic improvement in their aqueous solubility. Water-solublecyclodextrin derivatives of commercial interest include thehydroxypropyl derivatives of βCD and γCD, the randomly methylatedβ-cyclodextrin (RMβCD), and sulfobutylether β-cyclodextrin sodium salt(SBEβCD).

FIG. 4 and Table 1 were taken from an article entitled “Cyclodextrins”(A. Magnúsdóttir, M. Másson and T. Loftsson, J. Incl. Phenom. Macroc.Chem. 44, 213-218, 2002).

TABLE 1 Water solubility of cyclodextrins. Solubility MW ^(b) in water^(c) Cyclodextrin n R = H or Subst. ^(a) (Da) (mg/L) α-Cyclodextrin(αCD) 0 −H 0    972  145 β-Cyclodextrin (βCD) 1 −H 0   1135    18.52-Hydroxypropyl-β-cyclodextrin 1 −CH₂CHOHCH₃ 0.65 1400 >600 (HPβCD;Kleptose ® HPB) Sulfobutylether β-cyclodextrin 1 −(CH₂)₄SO₃Na⁺ 0.9 2163 >500 sodium salt (SBEβCD; Captisol ®) Randomly methylated β- 1 −CH₃1.8  1312 >500 cyclodextrin (RMβCD) γ-Cyclodextrin (γCD) 2 −H 0   1297 232 2-Hydroxypropyl-γ-cyclodextrin 2 −CH₂CHOHCH₃ 0.6  1576 >500 (HPγCD)^(a) Average number of substituents per glucose repeat unit; ^(b) MW:Molecular weight; ^(c) Solubilityin pure water at approx. 25° C.

Cyclodextrins create highly concentrated and water-soluble granules.Cyclodextrins are circular structures of sugar molecules that are knownto absorb other compounds into their center. They form inclusioncomplexes with poorly water-soluble compounds. Acting like a moleculemagnet, cyclodextrins absorb other molecules and assume theirproperties. These molecules can absorb up to 60% of their weight inalcohol while remaining in powdered form. It isn't until you mix themwith water that they dissolve.

Experiments with THC-cyclodextrin compounds increase THC watersolubility by nearly 1000 times. For this reason, in preferredembodiments, the emulsifying agent is a combination of at least twodifferent emulsifying agents with at least one being cyclodextrin andthe other emulsifying agent selected from the group consisting ofxanthan gum, guar gum, lecithin, carrageen, monoglycerides, naturalemulsifiers and organic emulsifiers that are safe for ingestion byhumans.

It is noted that cyclodextrin is very expensive and some versions evencause unwanted side effects when ingested. In the invention a lesseramount of cyclodextrin is used in combination with other emulsifiersthat are less costly to provide the same or better solubility results.This provides an economic solution to using a lesser amount ofcyclodextrin with the benefits at lower cost.

Lecithin

Lecithins are used in the invention as emulsifiers. They aresurface-active; simultaneous hydrophilic (water-loving) and hydrophobic(water-repelling) properties enable lecithins to make stable blends ofmaterials that otherwise do not mix easily and tend to separate.

Lecithin is a generic term to designate any group of yellow-brownishfatty substances occurring in animal and plant tissues, which areamphiphilic—they attract both water and fatty substances (and so areboth hydrophilic and lipophilic). Lecithins are generally used forsmoothing food textures, dissolving powders (emulsifying), homogenizingliquid mixtures, and repelling sticking materials. Lecithins arecomposed of phosphoric acid with choline, glycerol or other fatty acidsusually glycolipids or triglyceride. Glycerophospholipids in lecithininclude phosphatidylcholine, phosphatidylethanolamine,phosphatidylinositol, phosphatidylserine, and phosphatidic acid.

When added to Cannabis coconut oil lecithin increases absorption of THCand other cannabinoids into the cell membranes and speeds up theprocess.

Carrageen

Carrageens are a family of linear sulphated polysaccharides that areextracted from red edible seaweeds. They are widely used in the foodindustry, for their gelling, thickening, and stabilizing properties.Their main application is in dairy and meat products, due to theirstrong binding to food proteins. There are three main varieties ofcarrageenan, which differ in their degree of sulphation.Kappa-carrageenan has one sulphate group per disaccharide,Iota-carrageenan has two, and Lambda-carrageenan has three.

Monoglycerides

Monoglycerides are a class of glycerides which are composed of amolecule of glycerol linked to a fatty acid via an ester bond. Asglycerol contains both primary and secondary alcohol groups twodifferent types of monoglycerides may be formed; 1-monoacylglycerolswhere the fatty acid is attached to a primary alcohol, or a2-monoacylglycerols where the fatty acid is attached to the secondaryalcohol.

Monoglycerides are primarily used as surfactants, usually in the form ofemulsifiers. Together with diglycerides, monoglycerides are commonlyadded to commercial food products in small quantities which helps toprevent mixtures of oils and water from separating.

Base Oil

The base oil is present in the range of about 0.5 grams to 5 grams ofbase oil per 1 ounce of the composition.

The base oil is preferably in the range of about 0.1% to 40% of theemulsification.

The base oil is preferably selected from the group consisting ofvegetable glycerine, coconut oil and any oil high in saturated fats. Nutoils are also used in the invention process. The nut oils are selectedfrom the group consisting of almond oil, avocado oil, canola oil,coconut oil, corn oil, cottonseed oil, grapeseed oil, hazelnut oil,olive oil, extra virgin olive oil, palm oil, peanut oil, palm seed oil,pumpkin seed oil, safflower oil, sesame oil, soy oil, sunflower oil,vegetable oil and walnut oil.

Aqueous Vehicle

An aqueous vehicle is selected from the group consisting of coconutwater, fruit juice, milk and water. The aqueous vehicle is in the rangeof about 60% to 99.9% of the emulsification. The preferred vehicle iscoconut water.

In the emulsification the base oil to aqueous vehicle ratio is betweenabout 1 to 10 grams of base oil per 2 ounces of the emulsification.

Cannabis Oil

The Cannabis oil used in embodiments of the invention is in a purestate. This is important since the intended end use of the products ofthe invention are to be ingested by humans for medical or recreationaluse, where permitted.

The Cannabis oil used can be extracted from the marijuana plant by CO2extraction, water extraction, butane extraction and extraction methodsthat leave a zero testing for residuals. Representative structures ofthe Cannabis oil are illustrated in FIG. 1.

The Cannabis oil used in an embodiment of the invention is selected fromthe group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD)and other cannabinoid oils isolated from the marijuana plant.

For example, the Cannabis oil in the emulsification is in the range ofabout 5 mg to about 30 mg per about 2 ounces of the emulsification. TheCannabis oil in the sweetener is present in the range of about 1.5 mg toabout 20 mg per gram of sweetener. The Cannabis oil present in theelixir is in the range of about 3 mg to about 50 mg per ounce of elixir.In one embodiment, the Cannabis oil is not completely emulsified. TheCannabis oil remaining un-emulsified is absorbed by the body at adifferent/longer rate than the emulsified Cannabis oil.

Caffeine may be present/added in an embodiment of an emulsification inthe range of about 10 to about 300 mg per about 2 ounces of theemulsification. The caffeine can be in anhydrous form.

Sweetener

The Cannabis oil is added to the mixture and is present in the range ofabout 5 mg to 20 mg per about 2 ounces of the composition.

The sweetener is used in both the infused sweetener and white sugar,cane sugar, raw sugar, fructose, turbinado sugar, coconut sugar, datesugar, liquid stevia, liquid sugar, powdered sugar, brown sugar,muscovado sugar, honey, agave and other like sweeteners. The sweetenercomponent is present in the range of about 98% to about 99.88% of theCannabis infused sweetener or Cannabis infused elixir.

Water-Soluble Cannabinoid Composition

As a result of one invention method, a water-soluble cannabinoidcomposition is also provided that is bioavailable, fast acting andhighly metabolizable made of a base oil, a Cannabis oil, at least oneemulsifying agent and water.

The emulsifying agents in the cannabinoid composition are selected fromthe group consisting of xanthan gum, guar gum, cyclodextrin, lecithin,carrageen, monoglycerides, natural emulsifiers and organic emulsifiersthat are safe for ingestion by humans.

The base oil in the cannabinoid composition is preferably selected fromthe group consisting of vegetable glycerine, coconut oil and any oilhigh in saturated fats. However, other nut oils such as almond oil,avocado oil, canola oil, coconut oil, corn oil, cottonseed oil,grapeseed oil, hazelnut oil, olive oil, extra virgin olive oil, palmoil, peanut oil, palm seed oil, pumpkin seed oil, safflower oil, sesameoil, soy oil, sunflower oil, vegetable oil and walnut oil can be used asthe base oil.

A preferred emulsification used in the invention uses a base oil ofcoconut oil. Coconut oil is one of the best sources of healthy and“good” fatty acids.

The Cannabis oil in the composition is in a pure state that has beenextracted from the marijuana plant by CO2 extraction, water extraction,butane extraction and extraction methods that leave, a zero testing forresiduals.

The Cannabis oil in the composition is selected from the groupconsisting of tetrahydrocannabinol (THC), cannabidiol (CBD) and othercannabinoid oils isolated from the marijuana plant.

Other ingredients such as chocolate and liquor can be added to thecomposition to provide different flavor profiles.

Method of Making the Emulsifications

A method to produce the invention emulsifications, includes firstheating a base oil, preferably, extra virgin organic coconut oil tobetween about 120 to 220 degrees F. Pure extracted Cannabis oil is addedto the heated oil but may be added to the oil prior to heating. In ahigh speed blender (or similar machine) an aqueous vehicle, preferablycoconut water, is added to the coconut fat (oil) to ensureemulsification. While blending the heated mixture, adding at least oneemulsifying agent in the amount of about 0.15% and about 2% of the totalvolume of finished product, to the heated oil to create a mixture.Percentages used herein are on a dry weight basis and are based on thetotal volume of the finished product. The blender is run at high speedfor between about 30 seconds and about 2 minutes before adding theanhydrous caffeine in amounts ranging from about 10-300 mg.Alternatively, the caffeine can be added prior to adding the emulsifyingagent or at the same time. The resulting cannabinoid emulsification isbio-available, highly metabolizable and fast acting when ingested by theuser. The resulting emulsification is used to produce a line of THC andcaffeine infused emulsifications. The invention process makes theCannabis oil more bioavailable by making the oleo moleculewater-soluble. Thus, upon ingestion, making it fast acting, takingeffect in as little as about 15 minutes.

Other variations include various doses of Cannabis oil in the range ofabout 5 to 30 mg and different flavor profiles including lime,pomegranate, orange, lemon and others; and different serving sizesbetween about 1 and 64 oz.

The invention sweeteners are made by starting with high qualitysweeteners including sugar, coconut sugar, date sugar, stevia, and anyother quality sweeteners. The sweeteners are then infused withemulsified Cannabis oil using the process described below.

The Cannabis oil used is dissolved with alcohol, but it doesn't make theoil water-soluble. The invention emulsifying agents are needed to modifythe Cannabis oil from its natural hydrophobic state to a “water-loving”hydrophilic state. The amount of Cannabis oil used depends on thedesired potency, but preferably about 1 to about 10 grams of pureextracted Cannabis oil per pound of sweetener is used.

The amount of alcohol used in the invention process is typically 4 ozper lb of sugar. Preferably grain alcohol is used in the invention,although other similar alcohols can be used. At the end of the processthere is zero alcohol residue in the resulting product.

The Cannabis oil is placed in a water bath and heated to between about120 to 220 degrees F. for between about 4 and 30 minutes. The Cannabisoil is added to the alcohol and placed in a rotor blade machine and heldat a temperature between about 120° F. and 220° F. for between about 1-7minutes. During this process, an emulsifying agent, or combination ofemulsifying agents, is then added to the heated mixture in an amountbetween about 0.15% to 3% of the total weight of the finished product.

This mixture is then combined with the sweetener and is heated to about120 to about 220 degrees F. for about 10-60 minutes to complete theemulsification and to evaporate the residual alcohol from the sweetener.There is about 1 to about 4 grams of oil to about 4 oz of grain alcoholper pound of sweetener.

Possible variations include: percentage of emulsifier, from about 0.01%to 4%; the combination of emulsifiers to make up that percentage; thetemperature and time as mentioned in previous section. These sweetenersprovide a flexible, controllable, low-dose Cannabis experience,delivered in an understandable and desirable form. They can be used inbeverages, such as coffee or tea.

The invention sweeteners assure that the THC is both fast acting andhighly metabolizable. It assures that the consumer experiences aconsistent experience from ingesting the product, instead of having awide variation of experiences, including how long it takes to takeeffect, and how the effect will be each time.

The extracts of the invention can be mixed with other ingredients suchas soda and other like liquids.

The process for making the Cannabis infused elixirs of the invention isas follows. The elixirs are essentially syrups, fruit syrups, andvarious flavored and unflavored syrups. The ingredients to make a batchof the invention elixirs include an emulsifying agent in the amount ofabout 0.12 to about 2%. A gallon of fruit syrup; flavored or unflavoredand Cannabis oil in the amount between about 1000-2000 mg.

The syrup is heated to about 120-220 degrees F. The Cannabis oil isadded to this heated mixture and blended in a rotor for about 1 to 7minutes, during which time the emulsifier is added in. Each serving sizehas about 3 to 20 mg per ounce of water-soluble Cannabis oil.

Other variations include various doses of Cannabis oil in the range ofabout 5 to 30 mg and different flavor profiles including lime,pomegranate, orange, lemon and others; and different serving sizesbetween about 1 and about 64 oz.

The disclosure is further described with the help of the followingexamples. These examples, however, should not be construed to limit thescope of the disclosure.

Example 1

A Cannabis infused chocolate is provided that is bioavailable anddelivers fast acting effects of the Cannabis when ingested. The methodof making such includes use of about 5 to 10 oz of a base oil of eithervegetable glycerine or coconut oil. A high quality liquor such as cognacor whiskey can be added but is optional. The base oil liquid is heatedto between about 120 to 220° F. The Cannabis oil extract is added equalto about 110 to 1120 mg THC. The emulsifiers are added next, generallyin the following amounts: about 0.5% lecithin, 0.15% xanthan gum, about0.1% cyclodextrin. The emulsifiers can be used individually or incombination. The hot mixture is blended in a high speed blender or othermachine, run on high speed for about 2 minutes. The mixture is allowedto cool to room temperature.

After the mixture has cooled, about 10 lb of melted chocolate is addedand allowed to temper before depositing in a mold, then cooling to about55° F.

Example 2

Several experiments were run using several different emulsifiers andcombinations of different coconut oils: solid and liquid (MCT). (Note:liquid MCT is coconut oil that has medium chain triglyceride). Guar gum,lecithin, and cyclodextrin were tested as emulsifying agents andprovided good results. However, xanthan gum was the most effective andprovided the best emulsification of the oil and water, at the lowestviscosity.

The emulsification process that was determined the best had the addedeffect of making the THC more bioavailable by making the oleo moleculewater-soluble. This had another added effect of making it fast acting,taking effect in as little as about 15 minutes.

The method used to produce the invention emulsifications, included firstheating extra virgin organic coconut oil to between about 120 to about220 degrees F. CO₂ extracted Cannabis oil is added. In a high speedblender (or similar machine) coconut water is added to the coconut fat(oil) to ensure emulsification. While blending, xanthan gum powder isadded in an amount between about 0.15% and about 0.45% of the totalvolume of finished product. Percentages used herein are on a dry weightbasis and are based on the total volume of the finished product. Theblender is run at high speed for between 30 seconds and 2. The resultingemulsification is used to produce a variety of Cannabis infusedproducts. The invention process makes the THC more bioavailable bymaking the oleo molecule water-soluble. Thus, upon ingestion, making itfast acting, taking effect in as little as 15 minutes.

Example 3

A variety of Cannabis infused products were prepared and tested in arandom study group of 40 individuals. The products tested includedCannabis infused sugar, a cannabinoid/caffeine emulsification and aCannabis infused elixir and are summarized in the tables below.

Each of the 40 individuals tested one of the products from Tables 2, 3and 4. The breakdown of products tested was 10% (4 people) of thecannabinoid/caffeine emulsification; 20% (8 people) of cannabinoidelixirs and 70% (28 people) of the Cannabis infused sugar.

TABLE 2 Cannabis infused sugar (Serving size 1 tsp) Sugar Product #1 #2#3 #4 #5* Cannabis Oil (mg/tsp) 20 40 20 40 40 Sugar (lbs)  5  3 10  3  Alcohol (oz) 20 12 40 12  6 Lecithin (%)**  2  2  2  1  0 Cyclodextrin(%)**  0  0    0.03    0.12    0.25 *The sugar used in this sample wasmaple sugar. **% of final product.

TABLE 3 Cannabinoid/caffeine emulsification (Serving size 2 oz) Amountin Component emulsification THC (per serving)  10 mg Coconut Fat (SOLID)2.75% MCT 0.65% Coconut Water   96% Cyclodextrin 0.12% Xanthan Gum 0.12%Caffeine 1000 mg * Lime and coconut extract were added for flavor

TABLE 4 Cannabinoid elixirs (flavored syrups) (Serving size 1 oz) Amountin Component emulsification THC 10 mg/oz Flavored syrup 99.64%Cyclodextrin  0.16% Xanthan Gum  0.12% Cannabis Oil  0.04%

Participants in the study were asked a series of questions, the resultsof which are summarized in the tables below. Q1. How long until youexperienced an initial onset of effect after ingestion? The results arein Table 5. In all three products tested the onset of the Cannabiseffects were less than 15-20 min.

TABLE 5 Results for Onset of Effect Time >10 10-15 15-20 20-30 30-40 <40min min min min min min Sugar 10.71% 28.57%   32% 7.14% 7.14% 14.29%Emulsification 0 50% 50% 0 0 0 Elixir 12.4% 25% 25%  25% 12.5% 0

Q2. On a scale of 1 to 5, the participants were asked to describe thestrength of the initial onset experience after ingestion. A majority ofrespondents said the effects were mild to moderate. The results are inTable 6.

TABLE 6 Results for Strength Time 1 No effect 2 Very Mild 3 Mild 4Moderate 5 Strong Sugar 3.57% 3.57% 39.29% 46.43% 7.14% Emulsification 00  50%  50% 0 Elixir 0  25%  50%  12.5% 12.5%

Q3. Compared to other Cannabis edibles, the participants were asked howthey would characterize the rapidity of the onset of the products theytested. The respondents were comparing the invention products to otherproducts they ingested including gummy bears, brownies and baked goodscontaining Cannabis. The results are in Table 7.

TABLE 7 Results for Comparison to Other Cannabis Edibles 1 Much 2Somewhat 3 No 4 Somewhat 5 Much Time Slower slower difference fasterFaster Sugar 3.85% 3.85% 0 34.62% 57.69% Emulsification 0 0 0   75%  25% Elixir 0 0 0   25%   75%

In sum, in all embodiments, i.e. the Cannabis infused sugar,emulsification and elixir 92.7% to 100% said that the invention productsacted faster than other Cannabis edibles.

The water-soluble cannabinoid composition and caffeine emulsificationsof the invention provide a beneficial experience for people experiencinga variety of ailments: insomnia, muscle aches, anxiety, etc, or are inrecovery from surgery, or in chemotherapy. The emulsifications make theCannabis oil molecules hydrophilic, and thus water-soluble, which makesthe THC bioavailable, faster acting, and more highly metabolizable.

Medical marijuana patients are often challenged by the mediums they areoffered for consuming Cannabis. The water-soluble Cannabis of theinvention provides them a convenient, and smokeless, alternative toaccess the cannabinoids they need to alleviate their ailments.

The foregoing description of various and preferred embodiments of thepresent invention has been provided for purposes of illustration only,and it is understood that numerous modifications, variations andalterations may be made without departing from the scope and spirit ofthe invention as set forth in the claims. The preceding examples can berepeated with similar success by substituting the generically orspecifically described reactants and/or operating conditions of thisinvention for those used in the preceding examples.

Note that in the specification and claims, “about” or “approximately”means within twenty percent (20%) of the numerical amount cited.

Although the invention has been described in detail with particularreference to these embodiments, other embodiments can achieve the sameresults. Variations and modifications of the present invention will beobvious to those skilled in the art and it is intended to cover in theappended claims all such modifications and equivalents. The entiredisclosures of all references, applications, patents, and publicationscited above are hereby incorporated by reference.

What is claimed is:
 1. A cannabinoid infused ingestible compositioncomprising: a cannabinoid oil; a compound that forms an inclusioncomplex with the cannabinoid oil; and a thickener; wherein thecannabinoid oil is the only oil in the composition.
 2. The compositionof claim 1 further comprising a sweetener.
 3. The composition of claim 2wherein the sweetener is selected from the group consisting of whitesugar, cane sugar, raw sugar, fructose, turbinado sugar, coconut sugar,date sugar, stevia, liquid stevia, liquid sugar, powdered sugar, brownsugar, muscovado sugar, maple sugar, honey, and agave.
 4. Thecomposition of claim 1 wherein the compound comprises cyclodextrin. 5.The composition of claim 1 wherein the thickener comprises a gum.
 6. Thecomposition of claim 5 wherein the gum comprises xanthan gum.
 7. Thecomposition of claim 1 wherein the cannabinoid comprisestetrahydrocannabinol (THC) and/or cannabidiol (CBD).
 8. The compositionof claim 1 wherein the cannabinoid is bio-available, highlymetabolizable and fast acting when ingested.
 9. The composition of claim1 wherein the compound and the thickener each comprise 0.12% to 2% ofthe composition.
 10. The composition of claim 1 comprising 0.01% to 4%of both the compound and the thickener.
 11. The composition of claim 10comprising 0.15% to 3% of both the compound and the thickener.
 12. Thecomposition of claim 1 comprising equal percentages of the compound andthe thickener.
 13. A cannabinoid infused composition consistingessentially of: a cannabinoid oil; an alcohol; water; a compound thatforms an inclusion complex with the cannabinoid oil; and a thickener.14. The composition of claim 13 wherein the compound comprisescyclodextrin.
 15. The composition of claim 13 wherein the thickenercomprises a gum.
 16. The composition of claim 15 wherein the gumcomprises xanthan gum.
 17. The composition of claim 13 wherein thecannabinoid comprises tetrahydrocannabinol (THC) and/or cannabidiol(CBD).
 18. The composition of claim 13 wherein the cannabinoid isbio-available, highly metabolizable and fast acting when ingested. 19.The composition of claim 13 wherein the compound and the thickener eachcomprise 0.12% to 2% of the composition.
 20. The composition of claim 13comprising 0.01% to 4% of both the compound and the thickener.
 21. Thecomposition of claim 20 comprising 0.15% to 3% of both the compound andthe thickener.
 22. The composition of claim 13 comprising equalpercentages of the compound and the thickener.
 23. A cannabinoid infusedcomposition consisting essentially of: a cannabinoid oil; water; acompound that forms an inclusion complex with the cannabinoid oil; athickener; and a sweetener.
 24. The composition of claim 23 wherein thesweetener is selected from the group consisting of white sugar, canesugar, raw sugar, fructose, turbinado sugar, coconut sugar, date sugar,stevia, liquid stevia, liquid sugar, powdered sugar, brown sugar,muscovado sugar, maple sugar, honey, and agave.
 25. The composition ofclaim 23 wherein the compound comprises cyclodextrin.
 26. Thecomposition of claim 23 wherein the thickener comprises a gum.
 27. Thecomposition of claim 26 wherein the gum comprises xanthan gum.
 28. Thecomposition of claim 23 wherein the cannabinoid comprisestetrahydrocannabinol (THC) and/or cannabidiol (CBD).
 29. The compositionof claim 23 wherein the compound and the thickener each comprise 0.12%to 2% of the composition.
 30. The composition of claim 23 comprising0.01% to 4% of both the compound and the thickener.
 31. The compositionof claim 30 comprising 0.15% to 3% of both the compound and thethickener.
 32. The composition of claim 23 comprising equal percentagesof the compound and the thickener.
 33. A cannabinoid infused compositionconsisting essentially of: a cannabinoid oil; a compound that forms aninclusion complex with the cannabinoid oil; a thickener; and asweetener.
 34. The composition of claim 33 wherein the sweetener isselected from the group consisting of white sugar, cane sugar, rawsugar, fructose, turbinado sugar, coconut sugar, date sugar, stevia,liquid stevia, liquid sugar, powdered sugar, brown sugar, muscovadosugar, maple sugar, honey, and agave.
 35. The composition of claim 33wherein the compound comprises cyclodextrin.
 36. The composition ofclaim 33 wherein the thickener comprises a gum.
 37. The composition ofclaim 36 wherein the gum comprises xanthan gum.
 38. The composition ofclaim 33 wherein the cannabinoid comprises tetrahydrocannabinol (THC)and/or cannabidiol (CBD).
 39. The composition of claim 33 wherein thecompound and the thickener each comprise 0.12% to 2% of the composition.40. The composition of claim 33 comprising 0.01% to 4% of both thecompound and the thickener.
 41. The composition of claim 40 comprising0.15% to 3% of both the compound and the thickener.
 42. The compositionof claim 33 comprising equal percentages of the compound and thethickener.